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Studie - Overactive Bladder - Pipeline Review, H2 2011

Global Markets Direct

Global Markets Direct

10 / 2011
101 Seiten
Typ: Studie
Sprache: Englisch
Regionen: Europa, Asien / Pazifik, Mittlerer Osten / Afrika, Nordamerika / USA, Australien, Mittel- / Südamerika
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Overactive Bladder - Pipeline Review, H2 2011

Summary

Global Markets Direct’s, 'Overactive Bladder - Pipeline Review, H2 2011', provides an overview of the Overactive Bladder therapeutic pipeline. This report provides information on the therapeutic development for Overactive Bladder, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Overactive Bladder. 'Overactive Bladder - Pipeline Review, H2 2011' is built using data and information sourced from Global Markets Direct’s proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct’s team.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

- A snapshot of the global therapeutic scenario for Overactive Bladder.
- A review of the Overactive Bladder products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.
- Coverage of products based on various stages of development ranging from discovery till registration stages.
- A feature on pipeline projects on the basis of monotherapy and combined therapeutics.
- Coverage of the Overactive Bladder pipeline on the basis of route of administration and molecule type.
- Profiles of late-stage pipeline products featuring sections on product description, mechanism of action and research & development progress.
- Key discontinued pipeline projects.
- Latest news and deals relating to the products.

Reasons to buy

- Identify and understand important and diverse types of therapeutics under development for Overactive Bladder.
- Identify emerging players with potentially strong product portfolio and design effective counter-strategies to gain competitive advantage.
- Plan mergers and acquisitions effectively by identifying players with the most promising pipeline.
- Devise corrective measures for pipeline projects by understanding Overactive Bladder pipeline depth and focus of Overactive Bladder therapeutics.
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope.
- Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline.
Table of Contents

Table of Contents 2

List of Tables 7

List of Figures 8

Introduction 9

Global Markets Direct Report Coverage 9

Overactive Bladder Overview 10

Therapeutics Development 11

An Overview of Pipeline Products for Overactive Bladder 11

Overactive Bladder Therapeutics under Development by Companies 13

Overactive Bladder Therapeutics under Investigation by Universities/Institutes 15

Late Stage Products 16

Comparative Analysis 16

Mid Clinical Stage Products 17

Comparative Analysis 17

Early Clinical Stage Products 18

Comparative Analysis 18

Discovery and Pre-Clinical Stage Products 19

Comparative Analysis 19

Overactive Bladder Therapeutics - Products under Development by Companies 20

Overactive Bladder Therapeutics - Products under Investigation by Universities/Institutes 23

Companies Involved in Overactive Bladder Therapeutics Development 24

Allergan, Inc. 24

Antares Pharma, Inc. 24

Dainippon Sumitomo Pharma Co., Ltd. 25

American Oriental Bioengineering, Inc. 25

Astellas Pharma Inc. 26

Auxilium Pharmaceuticals, Inc. 26

Japan Tobacco Inc. 27

Kissei Pharmaceutical Co., Ltd. 27

Ono Pharmaceutical Co., Ltd. 28

Pfizer Inc. 28

Recordati S.p.A. 29

Teva Pharmaceutical Industries Limited 29

Merck KGaA 30

Hisamitsu Pharmaceutical Co., Inc. 30

Urigen Pharmaceuticals, Inc. 31

Plethora Solutions Holdings plc 31

KeyNeurotek Pharmaceuticals AG 32

Respiratorius AB 32

PharmEste 33

Hydra Biosciences, Inc. 33

Mt Cook Pharma. Inc. 34

Ion Channel Innovations, LLC 34

Overactive Bladder - Therapeutics Assessment 35

Assessment by Monotherapy Products 35

Assessment by Combination Products 36

Assessment by Route of Administration 37

Assessment by Molecule Type 39

Drug Profiles 41

SMP-986 - Drug Profile 41

Product Description 41

Mechanism of Action 41

R&D Progress 41

ASP3652 - Drug Profile 42

Product Description 42

Mechanism of Action 42

R&D Progress 42

YM905 - Drug Profile 43

Product Description 43

Mechanism of Action 43

R&D Progress 43

Betanis - Drug Profile 44

Product Description 44

Mechanism of Action 44

R&D Progress 44

UK-369003 - Drug Profile 45

Product Description 45

Mechanism of Action 45

R&D Progress 45

AA4010 - Drug Profile 46

Product Description 46

Mechanism of Action 46

R&D Progress 46

Anturol - Drug Profile 47

Product Description 47

Mechanism of Action 47

R&D Progress 47

APT - Drug Profile 48

Product Description 48

Mechanism of Action 48

R&D Progress 48

REC 0422 - Drug Profile 49

Product Description 49

Mechanism of Action 49

R&D Progress 49

REC 1819 - Drug Profile 50

Product Description 50

Mechanism of Action 50

R&D Progress 50

PSD506 - Drug Profile 51

Product Description 51

Mechanism of Action 51

R&D Progress 51

URG302 - Drug Profile 53

Product Description 53

Mechanism of Action 53

R&D Progress 53

XEN-D0501 - Drug Profile 54

Product Description 54

Mechanism of Action 54

R&D Progress 54

JTS-653 - Drug Profile 55

Product Description 55

Mechanism of Action 55

R&D Progress 55

KN203 - Drug Profile 56

Product Description 56

Mechanism of Action 56

R&D Progress 56

MK-4618 - Drug Profile 57

Product Description 57

Mechanism of Action 57

R&D Progress 57

ONO-8539 - Drug Profile 58

Product Description 58

Mechanism of Action 58

R&D Progress 58

ONO-8539 - Drug Profile 59

Product Description 59

Mechanism of Action 59

R&D Progress 59

KUC-7483 - Drug Profile 60

Product Description 60

Mechanism of Action 60

R&D Progress 60

Botox - Drug Profile 61

Product Description 61

Mechanism of Action 61

R&D Progress 61

Botox - Drug Profile 63

Product Description 63

Mechanism of Action 63

R&D Progress 63

Botox - Drug Profile 64

Product Description 64

Mechanism of Action 64

R&D Progress 64

MCP-202 - Drug Profile 66

Product Description 66

Mechanism of Action 66

R&D Progress 66

AGN-214868 - Drug Profile 67

Product Description 67

Mechanism of Action 67

R&D Progress 67

MCP-101 - Drug Profile 68

Product Description 68

Mechanism of Action 68

R&D Progress 68

AOBO-001 - Drug Profile 69

Product Description 69

Mechanism of Action 69

R&D Progress 69

THVD-201 - Drug Profile 70

Product Description 70

Mechanism of Action 70

R&D Progress 70

Bryophyllum Pinnatum - Drug Profile 71

Product Description 71

Mechanism of Action 71

R&D Progress 71

DR-3001 - Drug Profile 72

Product Description 72

Mechanism of Action 72

R&D Progress 72

HC-067047 - Drug Profile 73

Product Description 73

Mechanism of Action 73

R&D Progress 73

pVAX-hSlo - Drug Profile 74

Product Description 74

Mechanism of Action 74

R&D Progress 74

REC 0436 - Drug Profile 76

Product Description 76

Mechanism of Action 76

R&D Progress 76

TRPs antagonists - Drug Profile 77

Product Description 77

Mechanism of Action 77

R&D Progress 77

Second Generation Of TRPV1 Antagonists - Drug Profile 78

Product Description 78

Mechanism of Action 78

R&D Progress 78

Liposome Encapsulated Botulinum Toxin A - Drug Profile 79

Product Description 79

Mechanism of Action 79

R&D Progress 79

Tolterodine + Tamsulosin - Drug Profile 80

Product Description 80

Mechanism of Action 80

R&D Progress 80

TD9594 - Drug Profile 81

Product Description 81

Mechanism of Action 81

R&D Progress 81

THVD-101a - Drug Profile 82

Product Description 82

Mechanism of Action 82

R&D Progress 82

THVD-202 - Drug Profile 83

Product Description 83

Mechanism of Action 83

R&D Progress 83

THVD-302 - Drug Profile 84

Product Description 84

Mechanism of Action 84

R&D Progress 84

THVD-402 - Drug Profile 85

Product Description 85

Mechanism of Action 85

R&D Progress 85

THVD-502 - Drug Profile 86

Product Description 86

Mechanism of Action 86

R&D Progress 86

Targeted Toxin - Drug Profile 87

Product Description 87

Mechanism of Action 87

R&D Progress 87

HOB-294 - Drug Profile 88

Product Description 88

Mechanism of Action 88

R&D Progress 88

Overactive Bladder Therapeutics — Drug Profile Updates 89

Overactive Bladder Therapeutics - Discontinued Products 93

Overactive Bladder - Featured News 94

Aug 29, 2011: Astellas Pharma Announces Regulatory Submissions For Mirabegron For Overactive Bladder In US And Europe 94

Jul 01, 2011: Astellas Receives Approval For Betanis Tablet In Japan For Overactive Bladder 94

May 16, 2011: TheraVida Initiates Phase II Trial Of THVD-201 For Overactive Bladder And Urinary Incontinence 95

Apr 08, 2011: Antares Announces FDA Acceptance Of Anturol NDA For Filing 95

Mar 22, 2011: TheraVida Announces Positive Results From Phase I Trial Of THVD-201 96

Mar 21, 2011: Astellas Announces Encouraging Results From Phase III Study of Mirabegron In OAB 96

Mar 02, 2011: Syntaxin's Partner Allergan Initiates Two Phase II Trials With Re-Targeted Endopeptidase Drug 97

Feb 14, 2011: Antares Pharma Announces Receipt Of NDA User Fee Waiver 97

Jan 11, 2011: FemmePharma Completes FP 1097 Phase II Clinical Trial In Overactive Bladder 98

Dec 22, 2010: Antares Pharma Files New Drug Application For Anturol For Overactive Bladder 98

Appendix 100

Methodology 100

Coverage 100

Secondary Research 100

Primary Research 100

Expert Panel Validation 101

Contact Us 101

Disclaimer 101



List of Tables

Number of Products Under Development for Overactive Bladder, H2 2011 11

Products under Development for Overactive Bladder — Comparative Analysis, H2 2011 12

Number of Products under Development by Companies, H2 2011 14

Number of Products under Investigation by Universities/Institutes, H2 2011 15

Comparative Analysis by Late Stage Development, H2 2011 16

Comparative Analysis by Mid Clinical Stage Development, H2 2011 17

Comparative Analysis by Early Clinical Stage Development, H2 2011 18

Comparative Analysis by Discovery and Pre-Clinical Stage Development, H2 2011 19

Products under Development by Companies, H2 2011 20

Products under Development by Companies, H2 2011 21

Products under Development by Companies, H2 2011 22

Products under Investigation by Universities/Institutes, H2 2011 23

Allergan, Inc., H2 2011 24

Antares Pharma, Inc., H2 2011 24

Dainippon Sumitomo Pharma Co., Ltd., H2 2011 25

American Oriental Bioengineering, Inc., H2 2011 25

Astellas Pharma Inc., H2 2011 26

Auxilium Pharmaceuticals, Inc., H2 2011 26

Japan Tobacco Inc., H2 2011 27

Kissei Pharmaceutical Co., Ltd., H2 2011 27

Ono Pharmaceutical Co., Ltd., H2 2011 28

Pfizer Inc., H2 2011 28

Recordati S.p.A., H2 2011 29

Teva Pharmaceutical Industries Limited, H2 2011 29

Merck KGaA, H2 2011 30

Hisamitsu Pharmaceutical Co., Inc., H2 2011 30

Urigen Pharmaceuticals, Inc., H2 2011 31

Plethora Solutions Holdings plc, H2 2011 31

KeyNeurotek Pharmaceuticals AG, H2 2011 32

Respiratorius AB, H2 2011 32

PharmEste, H2 2011 33

Hydra Biosciences, Inc., H2 2011 33

Mt Cook Pharma. Inc., H2 2011 34

Ion Channel Innovations, LLC, H2 2011 34

Assessment by Monotherapy Products, H2 2011 35

Assessment by Combination Products 36

Assessment by Stage and Route of Administration, H2 2011 38

Assessment by Molecule Type, H2 2011 40

Overactive Bladder Therapeutics — Drug Profile Updates 89

Discontinued Products 93



List of Figures

Number of Products under Development for Overactive Bladder, H2 2011 11

Products under Development for Overactive Bladder — Comparative Analysis, H2 2011 12

Products under Development by Companies, H2 2011 13

Products under Investigation by Universities/Institutes, H2 2011 15

Late Stage Products, H2 2011 16

Mid Clinical Stage Products, H2 2011 17

Early Clinical Stage Products, H2 2011 18

Discovery and Pre-Clinical Stage Products, H2 2011 19

Assessment by Monotherapy Products, H2 2011 35

Assessment by Combination Products, H2 2011 36

Assessment by Route of Administration, H2 2011 37

Assessment by Stage and Route of Administration, H2 2011 38

Assessment by Molecule Type, H2 2011 39

Assessment by Stage and Molecule Type, H2 2011 40

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