Marktanalyse - Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline Review, H1 2012

Global Markets Direct

Global Markets Direct

4 / 2012
119 Seiten
Typ: Marktanalyse
Sprache: Englisch
Regionen: Europa, Asien / Pazifik, Mittlerer Osten / Afrika, Nordamerika / USA, Australien, Mittel- / Südamerika
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Acute Renal Failure (ARF) (Acute Kidney Injury) — Pipeline Review, H1 2012


Summary


Global Markets Direct’s, 'Acute Renal Failure (ARF) (Acute Kidney Injury) - Pipeline Review, H1 2012', provides an overview of the Acute Renal Failure (ARF) (Acute Kidney Injury) therapeutic pipeline. This report provides information on the therapeutic development for Acute Renal Failure (ARF) (Acute Kidney Injury), complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Acute Renal Failure (ARF) (Acute Kidney Injury). 'Acute Renal Failure (ARF) (Acute Kidney Injury) - Pipeline Review, H1 2012' is built using data and information sourced from Global Markets Direct’s proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct’s team.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.


Scope

- A snapshot of the global therapeutic scenario for Acute Renal Failure (ARF) (Acute Kidney Injury).
- A review of the Acute Renal Failure (ARF) (Acute Kidney Injury) products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.
- Coverage of products based on various stages of development ranging from discovery till registration stages.
- A feature on pipeline projects on the basis of monotherapy and combined therapeutics.
- Coverage of the Acute Renal Failure (ARF) (Acute Kidney Injury) pipeline on the basis of route of administration and molecule type.
- Profiles of late-stage pipeline products featuring sections on product description, mechanism of action and research & development progress.
- Key discontinued pipeline projects.
- Latest news and deals relating to the products.


Reasons to buy

- Identify and understand important and diverse types of therapeutics under development for Acute Renal Failure (ARF) (Acute Kidney Injury).
- Identify emerging players with potentially strong product portfolio and design effective counter-strategies to gain competitive advantage.
- Plan mergers and acquisitions effectively by identifying players with the most promising pipeline.
- Devise corrective measures for pipeline projects by understanding Acute Renal Failure (ARF) (Acute Kidney Injury) pipeline depth and focus of Acute Renal Failure (ARF) (Acute Kidney Injury) therapeutics.
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope.
- Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline.
Table of Contents

Table of Contents 2

List of Tables 7

List of Figures 8

Introduction 9

Global Markets Direct Report Coverage 9

Acute Renal Failure (ARF) (Acute Kidney Injury) Overview 10

Therapeutics Development 11

An Overview of Pipeline Products for Acute Renal Failure (ARF) (Acute Kidney Injury) 11

Acute Renal Failure (ARF) (Acute Kidney Injury) Therapeutics under Development by Companies 13

Acute Renal Failure (ARF) (Acute Kidney Injury) Therapeutics under Investigation by Universities/Institutes 15

Late Stage Products 17

Comparative Analysis 17

Mid Clinical Stage Products 18

Comparative Analysis 18

Early Clinical Stage Products 19

Comparative Analysis 19

Pre-Clinical Stage Products 20

Comparative Analysis 20

Acute Renal Failure (ARF) (Acute Kidney Injury) Therapeutics — Products under Development by Companies 21

Acute Renal Failure (ARF) (Acute Kidney Injury) Therapeutics — Products under Investigation by Universities/Institutes 22

Companies Involved in Acute Renal Failure (ARF) (Acute Kidney Injury) Therapeutics Development 23

FibroGen, Inc. 23

Novartis AG 24

Bayer AG 25

Cleveland BioLabs, Inc. 26

Torrent Pharmaceuticals Limited 27

Am-Pharma B.V. 28

AlloCure Inc. 29

Angion Biomedica Corp. 30

Thrasos, Inc. 31

CorMedix, Inc. 32

Exponential Biotherapies, Inc. 33

Action Pharma A/S 34

Kringle Pharma, Inc. 35

Nephrx Corporation 36

Acute Renal Failure (ARF) (Acute Kidney Injury) — Therapeutics Assessment 37

Assessment by Monotherapy Products 37

Assessment by Combination Products 38

Assessment by Route of Administration 39

Assessment by Molecule Type 41

Drug Profiles 44

FG-3019 - Drug Profile 44

Product Description 44

Mechanism of Action 44

R&D Progress 44

Protectan CBLB502 - Drug Profile 46

Product Description 46

Mechanism of Action 46

R&D Progress 46

Bovine Alkaline Phosphatase (iv) - Drug Profile 48

Product Description 48

Mechanism of Action 48

R&D Progress 48

EA-230 - Drug Profile 49

Product Description 49

Mechanism of Action 49

R&D Progress 49

EA-230 - Drug Profile 51

Product Description 51

Mechanism of Action 51

R&D Progress 51

BB3 - Drug Profile 53

Product Description 53

Mechanism of Action 53

R&D Progress 53

QPI 1002 - Drug Profile 54

Product Description 54

Mechanism of Action 54

R&D Progress 54

Eculizumab - Drug Profile 56

Product Description 56

Mechanism of Action 56

R&D Progress 56

ChronSeal - Drug Profile 57

Product Description 57

Mechanism of Action 57

R&D Progress 57

Lenalidomide + Dexamethasone - Drug Profile 58

Product Description 58

Mechanism of Action 58

R&D Progress 58

N-Acetylcysteine + Deferoxamine - Drug Profile 59

Product Description 59

Mechanism of Action 59

R&D Progress 59

Bortezomib + Dexamethasone + Doxorubicin - Drug Profile 61

Product Description 61

Mechanism of Action 61

R&D Progress 62

Acetylcysteine - Drug Profile 63

Product Description 63

Mechanism of Action 63

R&D Progress 63

Erythropoietin - Drug Profile 64

Product Description 64

Mechanism of Action 64

R&D Progress 64

Imatinib Mesylate - Drug Profile 65

Product Description 65

Mechanism of Action 65

R&D Progress 65

AP214 - Drug Profile 66

Product Description 66

Mechanism of Action 66

R&D Progress 66

Atorvastatin - Drug Profile 68

Product Description 68

Mechanism of Action 68

R&D Progress 68

Sodium Bicarbonate - Drug Profile 69

Product Description 69

Mechanism of Action 69

R&D Progress 69

Velcade + Dexamethasone - Drug Profile 70

Product Description 70

Mechanism of Action 70

R&D Progress 70

Bendavia - Drug Profile 72

Product Description 72

Mechanism of Action 72

R&D Progress 72

Fenoldopam - Drug Profile 73

Product Description 73

Mechanism of Action 73

R&D Progress 73

Ketanserin - Drug Profile 74

Product Description 74

Mechanism of Action 74

R&D Progress 74

CRMD-001 - Drug Profile 75

Product Description 75

Mechanism of Action 75

R&D Progress 75

NX001 - Drug Profile 76

Product Description 76

Mechanism of Action 76

R&D Progress 76

Bortezomib + Dexamethasone - Drug Profile 77

Product Description 77

Mechanism of Action 77

R&D Progress 77

Cyclophosphamide + Bortezomib + Dexamethasone - Drug Profile 79

Product Description 79

Mechanism of Action 79

R&D Progress 79

Curcumin - Drug Profile 81

Product Description 81

Mechanism of Action 81

R&D Progress 81

Nautiol - Drug Profile 82

Product Description 82

Mechanism of Action 82

R&D Progress 82

Pentoxifylline - Drug Profile 84

Product Description 84

Mechanism of Action 84

R&D Progress 84

Selenium - Drug Profile 85

Product Description 85

Mechanism of Action 85

R&D Progress 85

Fenoldopam - Drug Profile 86

Product Description 86

Mechanism of Action 86

R&D Progress 86

Furosemide - Drug Profile 87

Product Description 87

Mechanism of Action 87

R&D Progress 87

BCT197 - Drug Profile 88

Product Description 88

Mechanism of Action 88

R&D Progress 88

Mesenchymal Stromal Cells - Drug Profile 89

Product Description 89

Mechanism of Action 89

R&D Progress 89

HIF - Drug Profile 90

Product Description 90

Mechanism of Action 90

R&D Progress 90

THR-184 - Drug Profile 91

Product Description 91

Mechanism of Action 91

R&D Progress 91

AC607 - Drug Profile 93

Product Description 93

Mechanism of Action 93

R&D Progress 93

Intravenous Recombinant Alkaline Phosphatase - Drug Profile 95

Product Description 95

Mechanism of Action 95

R&D Progress 95

BR-5489 - Drug Profile 96

Product Description 96

Mechanism of Action 96

R&D Progress 96

Recombinant Human HGF - Drug Profile 98

Product Description 98

Mechanism of Action 98

R&D Progress 98

Acute Renal Failure (ARF) (Acute Kidney Injury) Therapeutics — Drug Profile Updates 100

Acute Renal Failure (ARF) (Acute Kidney Injury) Therapeutics — Discontinued Products 109

Acute Renal Failure (ARF) (Acute Kidney Injury) Therapeutics - Dormant Products 110

Acute Renal Failure (ARF) (Acute Kidney Injury) — Product Development Milestones 111

Featured News & Press Releases 111

Jan 05, 2012: AlloCure's Investigational Treatment For Acute Kidney Injury Receives Fast Track Designation From FDA 111

Nov 14, 2011: AlloCure Presents Safety And Preliminary Efficacy Of AC607 For Treatment Of Acute Kidney Injury At American Society Of Nephrology 111

Oct 03, 2011: Journal of Immunology Publishes Study Of Cleveland BioLabs's CBLB502 In Acute Renal Ischemic Failure 112

Sep 26, 2011: Action Pharma’s Phase IIb Clinical Trial With AP214 To Prevent Kidney Injury Associated With Major Cardiac Surgery Demonstrates Positive Top-Line Results 113

Sep 13, 2011: Thrasos Initiates Phase I Clinical Trial Of THR-184 In Acute Kidney Injury 114

Aug 08, 2011: Final Patient Completes Last Visit In Action Pharma’s Phase IIb Clinical Trial Of Ap214 115

Jun 21, 2011: CorMedix Announces SPA Agreement With FDA For Phase III Trial Of CRMD001 Study In Prevention Of CI-AKI 115

May 09, 2011: Action Pharma Completes Dosing In Phase IIb Clinical Trial With AP214 To Prevent Acute Kidney Injury Undergoing Cardiac Surgery 116

Jul 06, 2010: Angion Biomedica Receives Fast Track And Orphan Drug Designations From FDA For BB3 116

Mar 10, 2010: AM-Pharma Presents Positive Results of Its Phase II Clinical Trial With Alkaline Phosphatase in Acute Kidney Injury At The ISICEM Conference In Brussels 117

Appendix 118

Methodology 118

Coverage 118

Secondary Research 118

Primary Research 118

Expert Panel Validation 118

Contact Us 119

Disclaimer 119





List of Tables

Number of Products Under Development for Acute Renal Failure (ARF) (Acute Kidney Injury), H1 2012 11

Products under Development for Acute Renal Failure (ARF) (Acute Kidney Injury) — Comparative Analysis, H1 2012 12

Number of Products under Development by Companies, H1 2012 14

Number of Products under Investigation by Universities/Institutes, H1 2012 16

Comparative Analysis by Late Stage Development, H1 2012 17

Comparative Analysis by Mid Clinical Stage Development, H1 2012 18

Comparative Analysis by Early Clinical Stage Development, H1 2012 19

Comparative Analysis by Pre-Clinical Stage Development, H1 2012 20

Products under Development by Companies, H1 2012 21

Products under Investigation by Universities/Institutes, H1 2012 22

FibroGen, Inc., H1 2012 23

Novartis AG, H1 2012 24

Bayer AG, H1 2012 25

Cleveland BioLabs, Inc., H1 2012 26

Torrent Pharmaceuticals Limited, H1 2012 27

Am-Pharma B.V., H1 2012 28

AlloCure Inc., H1 2012 29

Angion Biomedica Corp., H1 2012 30

Thrasos, Inc., H1 2012 31

CorMedix, Inc., H1 2012 32

Exponential Biotherapies, Inc., H1 2012 33

Action Pharma A/S, H1 2012 34

Kringle Pharma, Inc., H1 2012 35

Nephrx Corporation, H1 2012 36

Assessment by Monotherapy Products, H1 2012 37

Assessment by Combination Products, H1 2012 38

Assessment by Stage and Route of Administration, H1 2012 40

Assessment by Stage and Molecule Type, H1 2012 43

Acute Renal Failure (ARF) (Acute Kidney Injury) Therapeutics — Drug Profile Updates 100

Acute Renal Failure (ARF) (Acute Kidney Injury) Therapeutics — Discontinued Products 109

Acute Renal Failure (ARF) (Acute Kidney Injury) Therapeutics — Dormant Products 110





List of Figures

Number of Products under Development for Acute Renal Failure (ARF) (Acute Kidney Injury), H1 2012 11

Products under Development for Acute Renal Failure (ARF) (Acute Kidney Injury) — Comparative Analysis, H1 2012 12

Products under Development by Companies, H1 2012 13

Products under Investigation by Universities/Institutes, H1 2012 15

Late Stage Products, H1 2012 17

Mid Clinical Stage Products, H1 2012 18

Early Clinical Stage Products, H1 2012 19

Pre-Clinical Stage Products, H1 2012 20

Assessment by Monotherapy Products, H1 2012 37

Assessment by Combination Products, H1 2012 38

Assessment by Route of Administration, H1 2012 39

Assessment by Stage and Route of Administration, H1 2012 40

Assessment by Molecule Type, H1 2012 41

Assessment by Stage and Molecule Type, H1 2012 42

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